Abstract
Chiral alkyl chlorides are useful substrates in synthesis due to their stereospecific reactivity with a range of nucleophiles. One of the most important processes to prepare optically active chlorinated compounds is through enantioselective α-halogenation reactions (see Review below). Building on previous work in fluorination reactions (Sodeoka and co-workers Angew. Chem. Int. Ed. 2007, 46, 5435), the authors present an asymmetric α-chlorination of oxazolidinone derivatives of arylacetic acid using a Ni/BINAP catalyst.
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