Abstract
Abstract We describe a convenient method for the synthesis of 1,2-disubstituted acetylenes via a cross-coupling reaction of (bromoethynyl)benzene with Grignard reagents. The reaction of (bromoethynyl)benzene (1 mmol) with Grignard reagent (1.3 mmol) mediated by NiCl 2 (4 mol%) and ( p -CH 3 Ph) 3 P (8 mol%) in THF could produce 1,2-disubstituted acetylenes in good yields at room temperature.
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