Nickel- and palladium-catalyzed cross-coupling as a route to 1- and 2-alkoxy- or dialkylaminovinylphosphonates

Abstract

1- and 2-alkoxy- or dialkylaminovinylphosphonates were synthesized using reactions of the corresponding vinylhalides with di- and triethylphosphites in the presence of catalytic amounts of Ni salts and Pd complexes. The best way for synthesis of 1-alkoxy or dialkylaminoderivatives is the Pd-catalyzed cross-coupling reaction with (EtO) 2POH and the best way for 2-alkoxy- or dialkylaminovinylphosphonates is the Arbuzov reaction with (EtO) 3P catalyzed by Ni salts.