Abstract
Abstract Lamprey and hagfish are the most ancient jawless vertebrates, which are serving as a “living fossil” of immunological origin and evolution. NICIP is a novel gene that we cloned from lamprey’s lymphocyte-like cells. Structural analysis indicates that NICIP contains two Ig-like domains, a PKD domain, a TM region and a cytoplasm immunoreceptor tyrosine-based activation motifs (ITAM) region. It belongs to IgSF family and may involve in immune response, cell signaling and other functions. Our present research showed that there are interaction between NICIP and VLR, and this interaction can effectively inhibit VLR to transduce signal to intracellular.
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