Niceritrol 単回投与の血清脂質に及ぼす即時的効果についての検討

Abstract

In this study, the changes of the levels of serum lipids after single administration of Niceritrol (Perycit-Sanwakagaku) were observed.The study was performed on 14 healthy controls and 31 patients with lipid disorders. One capsule containing 250mg Niceritrol was administered to each subject. Blood was collected before, one hour after and two hours after Niceritrol administration.Lipoprotein fraction cholesterol was measured by gel electrophoresis and gas-liquid chromatography (GLC). The fractions of free fatty acid (FFA) were also measured by GLC.Results:1) Both in the healthy control group and in the patient group, α, pre β and β-lipoprotein cholesterol showed no significant change by Niceritrol administration.2) The levels of serum total cholesterol also changed in neither group.3) The levels of serum triglyceride decreased mildly but significantly in the healthy controls, but in the patient group, it showed no change.4) In healthy controls, serum FFA decreased distinctly one hour after administration, but two hours after, it increased again. And such tendency was more prominent in females than in males. Each fraction of FFA changed in parallel with the change of total FFA. In the patient group, slight decrease of FFA was observed, but it was not statisticaly significant.Conclusion:The most prominent change of serum lipid observed in this study was the decrease of FFA in healthy controls. This chage was thought to be the result of supression of hydrolysis of triglyceride by Niceritrol in adipose tissue. Such effect of Niceritrol was not observed in patients in this study, therfore these results indicate that there is some metabolic disorder of triglyceride in adipose tissue level in these patients.