Abstract
It has been known for decades that clathrin- and dynamin-mediated endocytosis is the major pathway for recycling the components of vesicle membranes after strong stimulation and high rates of exocytosis in secretory cells. This pathway occurs over tens of seconds to minutes after fusion of the secretory vesicle membrane with the plasma membrane. It resembles classical receptor-mediated endocytosis, but it has a trigger that is unique to secretion: the sudden appearance of the secretory vesicle membrane on the surface of the cell. However, the spatial localization, the relationship to individual fusion events, the nature of the cargo, and the timing and nature of nucleation events have been unknown. An elegant study by Mary Bittner, Rachel Aikman, and Ronald Holz has addressed these issues.
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