Abstract
We asked George Koob, Ph.D., director of the National Institute on Alcohol Abuse and Alcoholism (NIAAA), about his reflections on combining alcohol and cannabis. While it's obvious that established central nervous depressants like opioids or benzodiazepines would, when combined with alcohol, cause serious problems, what about tetrahydrocannbinol (THC), the active ingredient of cannabis? “My usual explanation for any combination of alcohol and a sedative hypnotic or an opioid is 2 plus 2 equals 5,” Koob told us last month. This would apply also to “any drug that slows you down – and THC slows you down,” he added. “The interaction with alcohol is pretty dramatic” for such drugs.
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