Abstract
Cyclopentenone derivatives are obtained from alkynes, allyl halides and carbon monoxide in a single synthetic operation by the use of Ni(COD) 2 with minimal formation (if any) of Ni(CO) 4. The initial formation of a π-allyl nickel complex, first intermediate in the so far postulated mechanism, is a valid pathway to the three component cycloaddition. However, care should be taken to minimize the side reactions in the process, the extension of which depends on the nature of both the alkyne and the allyl derivatives. Reliable monitoring of the components throughout the process results in good yields of the cycloadducts.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
