N-Heterocyclic Analogs: A New Prospect in Cancer Therapy

Abstract

One of the serious problems in the healthcare industry is cancer. In today’s scenario, a lot of anticancer medications are available in themarket, but they are not specific for specific cancer or have poor safety value, adverse effects and high resistance. Therefore, the designing of safer and more focused anticancer medications is essential. In today’s situation, more than 85% of all medications with good physiological activity are heterocyclic compounds with one or more heteroatoms in the aromatic structure. The most common aromatic moieties that have the highest prevalence in anticancer medication are nitrogen-containing heterocycles. The information about the synthesis and anticancer activity of various N-containing derivatives, such as pyridine, pyrimidine, carbazole, indole, imidazole, benzimidazole, quinoline, isatin, pyrazole and triazole, has been summarized which directly indicates their anticancer potentiality against different types of cancer. The study also showed that in contrast to other substituents, the substitution of electron-withdrawing groups on the heterocyclic Ncontaining moiety has greater anticancer action. The information in this work might serve as a model for future investigations into the production and anticancer properties of novel N-containing heterocyclic compounds.