Abstract
Many polypeptides of therapeutic and diagnostic interest that are being produced in recombinant form for in-vivo administration carry, in their native form, N-linked oligosaccharides. In this article we review certain biosynthetic aspects and functional consequences of N-glycosylation that are relevant to the production and administration of recombinant glycoproteins. In so doing, we hope to increase awareness of the biological significance of N-linked oligosaccharides, and to emphasize the need to consider the N-glycosylation of a recombinant glycoprotein prior to therapeutic administration.
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