Abstract
This study was performed to evaluate the effect of isoflavones extracted from soy germ on menopausal symptoms associated with 4-vinyl cyclohexene diepoxide (VCD)-induced follicular failure in mice. Total isoflavone extract (CE) and aglycone-enriched extract (TPCa) from soybean embryos 50 mg/kg/day were both able to improve female physiological characteristics positively. The CE sample was able to slightly increase the uterine volume (p<0.001), increase the number of primary follicles (p<0.001), and increase the estradiol content (p<0.001). TPCa sample also can slightly increase uterine volume (p<0.05), increase the number of primary follicles (p<0.001), and increase estradiol content (p<0.001). These results suggest the potential for using isoflavones from soybean embryos in the prevention and treatment of menopausal symptoms - more effectively and safely than traditional hormone therapy.
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