Nghiên cứu độc tính cấp và độc tính bán trường diễn của viên nang cứng Định Thống Phong trên động vật thực nghiệm

Abstract

Research to evaluate acute toxicity and sub-chronic toxicity of Dinh Thong Phong capsule (DTP) in experimental animals. Acute toxicity was evaluated in mice follow the method described by Litchfield- Wilcoxon, the OECD guideline and the guideline of Ministry of Health of Vietnam; sub-chronic toxicity was evaluated in rats according to OECD 407 Guideline. In acute toxicity study, no death or toxic signs were observed with DTP capsule administration, DTP capsule did not exhibit acute toxicity up to a dose of 4800 mg/kg. In sub-chronic toxicity, DTP capsule at doses of 500 mg/kg and 1500 mg/kg were had not affect to the body weight; some hematological parameters; AST, ALT, albumin, total cholesterol and creatinine levels; and macroscopic, microscopic images of liver, spleen and kidney of rats when taken continuously for 56 days.