Nghiên cứu đặc điểm mô bệnh học và hóa mô miễn dịch của ung thư phổi tại Khoa Giải phẫu bệnh - Bệnh viện Trung ương Huế

Abstract

The diagnosis and classification of lung cancer histology often face to many difficulties in pathological practice, especially on small core biopsies. Therefore, there is a need the immunohistochemistry for determining the exact types of histopathology, reflecting prognosis and indications for treatment of lung cancer. Objective: Evaluation characteristics histological of lung cancer. Applying the revealing of immunohistochemistry to classify the lung cancer. Matherial and Method: Through a study on 124 patients were diagnosed as lung cancer at Hue Central Hospital from June, 2016 to June, 2019. Prospective, descriptive, cross- sectional study. Results: - Ratio Male: Female: 2,45 / 1. The average age is disease 54,16 ± 12, the lowest age: 17, maximum: 77. The highest group is 50-69 years old (58,07%). The two most common types of histology are adenocarcinoma (46.77%), squamous cell carcinoma (30.65%), Small cell mesothelioma accounts for a very low rate (5.65%). - On the expression of immunohistochemistrical markers in adenocarcinoma: CK7 (+): 98.28%; TTF1 (+): 96.55%; CK5 / 6 (-): 100%, in squamous cell carcinoma: CK5 / 6 (+): 92.11%. P63 (+): 52.63%, TTF1 (-): 100%. Conclusion: The expression of immunohistochemistrical markers such as CK7, TTF1, CK 5/6, P63 distinguishes between the gland cells and squamous cell, while immunohistochemistrical markers such as TTF1, NSE, Synaptophysin, Chromogranin to identify small cell carcinoma of the lung are very useful in diagnosing, classifying and treating the lung cancer.