Nghiên cứu đặc điểm lâm sàng, cận lâm sàng và kết quả điều trị ung thư biểu mô tuyến vú ở phụ nữ lớn tuổi

Abstract

Background: Increasing age is the most prevalent, primary risk factor for breast cancer. However, the treatment of breast cancer in older women were less active than younger women and there is a relative lack of evidence-based guidelines to inform the treatment of breast cancer in elderly woman. In this study, we evaluated the results of treatment of breast cancer in elderly woman based on the tumor characteristics. Material and methods: This study was designed with 60 breast cancer patients older than 65 years old. Evaluation of clinical, subclinical characteristics and treatment results initially (disease-free survival and total survival after 2 years) of this group. Results: We conducted a study of 60 elderly woman with breast cancer. The majority of patients with invasive ductal carcinoma (90%), histological grade I, II (76,3%) and the patients with stage I, II disease were 80,4%. The older patients have been found to have a greater frequency of molecular subtypes: luminal A and B (34% and 22%), however the triple-negative/basal-like was 28%. The rate of modified radical mastectomy was 93,3%, only 46,4% of patients received adjuvant therapy (chemotherapy, radiation therapy, hormonal therapy and antibody therapy). Local recurrence and distant metastasis were 11,7% and 18,3%, mortality was 16,7% with a median follow-up of 28,03 months. Conclusions: Breast carcer in older patients has better prognosis factors than younger women. However, current adjuvant systemic therapy options for older women with breast cancer was not clear.