Next-Generation Ultrasol Curcumin Boosts Muscle Endurance and Reduces Muscle Damage in Treadmill-Exhausted Rats.

Emre Sahin,Cemal Orhan,Muralidhara Padigaru,Manutosh Acharya,Kazim Sahin,Fusun Erten,Besir Er,Abhijeet A Morde

doi:10.3390/antiox10111692

Emre Sahin, Cemal Orhan + Show 6 more

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https://doi.org/10.3390/antiox10111692

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Abstract

Curcumin positively affects performance during exercise and subsequent recovery. However, curcumin has limited bioavailability unless consumed in larger doses. In the current study, we examined the impact of a new formulation of curcumin, Next-Generation Ultrasol Curcumin (NGUC), which is relatively more bioavailable than natural curcumin on exhaustion time, grip strength, muscle damage parameters, and serum and muscle proteins. A total of 28 rats were randomly grouped as control (C, non-supplemented), exercise (E, non-supplemented), E+NGUC100 (supplemented with 100 mg/kg BW NGUC), and E+NGUC200 (supplemented with 200 mg/kg NGUC). Grip strength and exhaustion time were increased with NGUC supplementation (p < 0.0001). Creatine kinase (CK), lactate dehydrogenase (LDH), lactic acid (LA), myoglobin, malondialdehyde (MDA) concentrations were reduced in serum, and muscle tissue in NGUC supplemented groups (p < 0.05). In contrast, NGUC supplementation elevated the antioxidant enzyme levels compared to the non-supplemented exercise group (p < 0.01). Additionally, inflammatory cytokines were inhibited with NGUC administration (p < 0.05). NGUC decreased PGC-1α, p-4E-BP1, p-mTOR, MAFbx, and MuRF1 proteins in muscle tissue (p < 0.05). These results indicate that NGUC boosts exercise performance while reducing muscle damage by targeting antioxidant, anti-inflammatory, and muscle mass regulatory pathways.

Highlights

The beneficial effects of regular physical activity on improving insulin sensitivity, limiting metabolic syndrome, reducing blood pressure, and improving muscle metabolic activity and antioxidant function have been previously established [1,2,3,4]
The body weights (BW) of rats did not change with Next-Generation Ultrasol Curcumin (NGUC) supplementation (Figure 1A, p > 0.05)
The previous studies reported that curcumin supplementation increased the PGC-1α protein levels or deacetylation in muscle tissue [13,28,29], we found that NGUC supplementation suppresses the muscle

Summary

Introduction

The beneficial effects of regular physical activity on improving insulin sensitivity, limiting metabolic syndrome, reducing blood pressure, and improving muscle metabolic activity and antioxidant function have been previously established [1,2,3,4]. The oxygen utilization rate in the mitochondria increases during exercise, and it induces the release of free radicals and reactive oxygen species (ROS) in the cell. Exhaustive types of exercise routines may trigger the excessive production of ROS, inducing inflammatory reactions [5], and increasing proinflammatory cytokines [6], leading to muscle damage and fatigue [7]. Antioxidant supplementation, notable polyphenols, offers opportunities to attenuate muscle damage, fatigue, and inflammatory activity [6,8] and limit muscle atrophy [9]. Antioxidant supplementation, notable polyphenols, offers opportunities to attenuate muscle damage, fatigue, and inflammatory activity [6,8] and limit muscle atrophy [9]. 4.0/).

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