Abstract
Next-Generation Sequencing
Highlights
Many layers of epigenomic information are being mapped by next-generation sequencing
Parallel sequencing have been applied to microRNA and mRNA profiling (RNA-Seq) to more accurately measure expressions of microRNA and mRNA, identify variability in microRNA sequence and mRNA sequence, and detect splice form of mRNA expressions
We briefly describe the papers in the following
Summary
Many layers of epigenomic information are being mapped by next-generation sequencing. Starting in 2005, a variety of massively parallel sequencing instruments such as the Roche/454, the Life Technologies SOLiD, and the Illumina platforms which were largely different from the Sanger-based capillary sequencing were used to sequence the human and model organism genomes. Parallel sequencing have been applied to microRNA and mRNA profiling (RNA-Seq) to more accurately measure expressions of microRNA and mRNA, identify variability in microRNA sequence and mRNA sequence, and detect splice form of mRNA expressions.
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