Abstract
The processes initiating atherosclerosis that eventually lead to all the well-known complications of the disease have long been debated. Now, Borén and coworkers provide convincing data on the first steps of atherogenesis [ 1. Skålén K. et al. Subendothelial retention of atherogenic lipoproteins in early atherosclerosis. Nature. 2002; 417: 750-754 Crossref PubMed Scopus (714) Google Scholar ]. Their findings indicate that the central event in the development of atherosclerosis is the retention of low-density lipoprotein (LDL) by proteoglycans present in the subendothelium. In particular, stretches of basic amino acids in LDL bind to the negatively charged sulfate groups of the proteoglycans.
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