Abstract
The 52nd meeting of the European Pancreatic Club was organized and conducted online in Paris on July 2–3, 2020. It is the first time the Congress took place online, with about a thousand of pancreatologists having participated in it. The high scientific, organizational and technical level of the congress should be noted.
 This review presents the most interesting research results in the following sections: anatomy of the pancreas, acute early chronic, autoimmune pancreatitis, cancer and other malignant pancreatic diseases, functional pancreatic insufficiency, enzyme replacement therapy, pancreatic steatosis, microbiota in pancreatic pathology.
 Dugic et al. (Sweden) conducted a systematic review “The effect of anatomical variants of the Wirsung’s duct on exocrine function and risk of pancreatic pathology”. Studies of the MEDLINE database from 1960 to 2019 were analyzed; data of 3234 patients were included. A classification of anatomical variants of the pancreatic duct system was compiled.
 A lecture by T. B. Gardner (Great Britain) on pancreatic steatosis drew great attention. The problem of pancreatic steatosis is surrounded by a number of unresolved issues; the terminology of pancreatic steatosis itself is unclear. Under conditions of oxidative stress, cytokines released from adipocytes trigger the local inflammation and dysfunction of the affected pancreatic cells. The pathogenesis of pancreatic steatosis requires further studies.
 The symposium on exocrine pancreatic insufficiency in pancreatic cancer played the central role in the congress. Professor E. Dominguez-Munoz (Spain) gave a lecture within the framework of the symposium. 80% of patients with pancreatic cancer have sarcopenia and/or cachexia. Sarcopenia and cachexia in pancreatic adenocarcinoma are the most obviousamong all tumor localizations. The pathogenesis of cachexia and sarcopenia in pancreatic cancer was analyzed in detail; the necessity of enzyme replacement therapy with Creon was substantiated. Particular attention was paid to the pathogenesis of pancreatic insufficiency after surgical treatment (pancreatic resections, pancreatectomy); the features of replacement therapy were highlighted.
 The meeting of the European Pancreatic Club, as usual, was informative and interesting
Highlights
2−3 июля 2020 г. состоялась 52-я встреча Европейского Клуба Панкреатологов, которая была организована в Париже и проведена on-line
This review presents the most interesting research results : anatomy of the pancreas, acute early chronic, autoimmune pancreatitis, cancer and other malignant pancreatic diseases, functional pancreatic insufficiency, enzyme replacement therapy, pancreatic steatosis, microbiota in pancreatic pathology
The pathogenesis of cachexia and sarcopenia in pancreatic cancer was analyzed in detail; the necessity of enzyme replacement therapy with Creon® was substantiated
Summary
Во всех случаях изменения выявлены только при АИП 1-го типа. Поражение легких при АИП 1-го типа (КТ): A) до лечения; B) после лечения кортикостероидами. В исследование были включены 345 пациентов с ожирением (индекс массы тела (ИМТ) >25 кг/м2). УЗИ выявило стеатоз печени у 280 (81%) пациентов и ЖКБ у 52 (15,1%). У пациентов с ожирением наибольший относительный риск развития имел стеатоз печени — 12,174 (95% доверительный интервал (ДИ) 6,221−23,824). В то же время стеатоз печени в сочетании с ХП был диагностирован у 121 пациента, ЖКБ в сочетании с ХП — у 35 пациентов. Пример саркопенического ожирения при ХП: ИМТ 27 кг/м2, снижено содержание фекальной эластазы; саркопения и увеличение объема висцерального жира (мышцы — красный цвет, подкожный жир — зеленый цвет, висцеральный жир — желтый цвет). Выявлены (с помощью КТ, УЗИ) 192 больных с НАЖБ ПЖ Это представляет собой явное преимущество препарата Креон®, т. к. высвободившийся при рН 4−5 панкреатин подвергается частичной инактивации (рис. 22)
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