Abstract
Renal and nonrenal mechanisms are involved in the long-term regulation of blood pressure that is dependent on a precise balance among humoral agents and vasoconstrictor and vasodilator hormones and other factors that act to increase or decrease renal sodium transport. These imply a complex interaction between natriuretic and antinatriuretic systems. The dysregulation of ion transport intrinsic and extrinsic to the kidney has been proposed to cause essential hypertension. See Article by Salo et al An important natriuretic system is that comprising the cardiac hormones, atrial natriuretic peptide (ANP), and brain natriuretic peptide (BNP), playing a critical role in the reduction of blood pressure and cardiac disorders with relevance to renal and cardiovascular homeostasis. ANP is synthesized and stored in the atrial granules as a prohormone with 126 amino acids, proANP. BNP is deglycosylated from a 108-amino acid prohormone, proBNP, and further processed into an amino …
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