Abstract
The synthesis of several metal complexes of d-block elements of hexadecanoic acid (palmitic acid) and its antimicrobial activity was reported in this study. UV-Vis and FT-IR spectroscopy studies were used to characterize and confirm the produced metal complexes by the shift in the absorbance and the formation of M-O linkage. The X-ray diffraction method was mainly used to examine the crystallographic faces of the complexes based on the transition metals. Thermal gravimetric investigation revealed that all metal palmitate complexes had high thermal stability in the range of 250-300°C. The metal complexes of hexadecanoic acid were examined for microbicidal activity against diverse bacterial strains and fungal pathogens using the agar well diffusion method. The copper palmitate complex presented excellent antibacterial activity among the other metal complexes. These outcomes suggest of using fatty acid metal complexes as a suitable candidate in several biomedical applications.
Highlights
Metal-ligand complexes have gained much importance in biomedical research, owing to their physicochemical features, as well as their numerous oxidation states and stereochemistry, which make them ideal candidates for the establishment of innovative metal-based therapeutic agents.depending on the structure of the ligand, the biological effects and reactivity of metal-based medications can be modified
Hexadecanoic acid is formed during fatty acid synthesis
In the binary solvent medium, metal palmitate complexes were synthesized by simple method through the interaction of respective metal ions with hexadecanoic acid
Summary
Metal-ligand complexes have gained much importance in biomedical research, owing to their physicochemical features, as well as their numerous oxidation states and stereochemistry, which make them ideal candidates for the establishment of innovative metal-based therapeutic agents. Hexadecanoic acid is formed during fatty acid synthesis (lipogenesis) As a result, it is found in adipose tissue [1] and breast milk of humans [2]. Saturated fatty acids with longer chain length like palmitic acid have been reported as potential antibacterial agents (gram positive and negative bacterial strains) for more than two decades [5,6,7,8,9]. No comprehensive reports or research on the metal complexes of saturated fatty acid for antimicrobial infections are not done. In this present research work, we study the synthesis of various transition metals (M = Mn, Co, Ni, Cu, and Zn) complex with hexadecanoic acid. Ous metal coordinated complexes of hexadecanoic acid has been well discussed
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