Abstract
Enteroviruses (EVs) are a group of human and animal viruses that are capable of causing a variety of clinical syndromes. Different genotypes classified into species can be distinguished on the basis of sequence divergence in the VP1 capsid-coding region. Apparently new genotypes are discovered regularly, often as incidental findings in studies investigating respiratory syndromes or as part of poliovirus surveillance. Recently, some EVs have become recognized as significant respiratory pathogens, and a number of new genotypes belonging to species C have been identified. The circulation of these newly identified species C EVs, such as EV-C104, EV-C105, EV-C109, and EV-C117, nevertheless appears to be limited. In this report, we show the results of routine genotyping of all enteroviruses detected in our tertiary care hospital between January 2008 and April 2015. We detected 365 EVs belonging to 40 genotypes. Interestingly, several newly identified species C EVs were detected during the study period. Sequencing of the 5′ untranslated region (5′ UTR) of these viruses shows divergence in this region, which is a target region in many detection assays.
Highlights
The University of Groningen, University Medical Center Groningen, Department of Medical Microbiology, Division of Clinical Virology, Groningen, the Netherlands
EV type is capable of causing a variety of clinical syndromes and that a particular clinical syndrome may be caused by a variety of EV types
The EV genotype that was most frequently detected during the study period was EV-D68
Summary
EVs were classified according to clinical, serological, and culture characteristics, but currently, sequence divergence in the VP1 capsid-coding region is used for allocation of these viruses into different genotypes. Some clinical conditions are classically associated with one or more EV genotypes, such as AFP, which before mass vaccination used to be most commonly caused by polioviruses, it is apparent that each. EV-A71, which causes HFMD, is capable of causing neurological infections [5]. Neurological infections as well as HFMD can be caused by a variety of EV genotypes [6, 7]. Many countries have a surveillance system at the national level for cases of AFP and neurological infections caused by EVs other than poliovirus [8, 9]. Data about circulating EV genotypes are thereby generated, but these data are not comprehensive
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