Abstract
BackgroundThree* human polyomaviruses have been discovered recently, KIPyV, WUPyV and MCPyV. These viruses appear to circulate ubiquitously; however, their clinical significance beyond Merkel cell carcinoma is almost completely unknown. In particular, nothing is known about their preponderance in vertical transmission. The aim of this study was to investigate the frequency of fetal infections by these viruses. We sought the three by PCR, and MCPyV also by real-time quantitative PCR (qPCR), from 535 fetal autopsy samples (heart, liver, placenta) from intrauterine fetal deaths (IUFDs) (N = 169), miscarriages (120) or induced abortions (246). We also measured the MCPyV IgG antibodies in the corresponding maternal sera (N = 462) mostly from the first trimester.ResultsNo sample showed KIPyV or WUPyV DNA. Interestingly, one placenta was reproducibly PCR positive for MCPyV. Among the 462 corresponding pregnant women, 212 (45.9%) were MCPyV IgG seropositive.ConclusionsOur data suggest that none of the three emerging polyomaviruses often cause miscarriages or IUFDs, nor are they transmitted to fetuses. Yet, more than half the expectant mothers were susceptible to infection by the MCPyV.
Highlights
Three* human polyomaviruses have been discovered recently, KI polyomavirus (KIPyV), WU polyomavirus (WUPyV) and Merkel cell polyomavirus (MCPyV)
Among the five* human polymaviruses known, aside from the BK virus (BKV) and JC virus (JCV) [1,2], three* new ones, KI polyomavirus (KIPyV), WU polyomavirus (WUPyV), and Merkel cell polyomavirus (MCPyV) have been discovered during the past few years by use of advanced molecular techniques [3,4,5]. In their DNA sequences, KIPyV and WUPyV are interrelated more than MCPyV, which differs from all the human polyomaviruses known [6]
The KIPyV and WUPyV were discovered in nasopharyngeal aspirates (NPA) from children with respiratory tract infections [3,4]
Summary
Three* human polyomaviruses have been discovered recently, KIPyV, WUPyV and MCPyV These viruses appear to circulate ubiquitously; their clinical significance beyond Merkel cell carcinoma is almost completely unknown. Among the five* human polymaviruses known, aside from the BK virus (BKV) and JC virus (JCV) [1,2], three* new ones, KI polyomavirus (KIPyV), WU polyomavirus (WUPyV), and Merkel cell polyomavirus (MCPyV) have been discovered during the past few years by use of advanced molecular techniques [3,4,5]. IgM studies of BKV and JCV in cord blood samples showed no apparent association with congenital infection [27,28]
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