Newly diagnosed abnormal glucose tolerance in patients with acute coronary syndrome and without known diabetes mellitus

Abstract

To investigate the prevalence of newly diagnosed abnormal glucose tolerance in patients with acute coronary syndrome and without known diabetes mellitus (DM) and to access the correlation of glycometabolic abnormality with traditional risk factors of cardiovascular diseases. The clinical data of 1328 patients with cute coronary syndrome (ACS), without previous DM, and with the admission blood glucose < 11.1 mmol/ who were consecutively admitted in 52 hospitals of 7 cities in China from June 1 to August 31 2005, were collected. A simple oral glucose tolerance test (OGTT) was conducted before they were discharged. Glycometabolic perturbation was seen in 887 of the 1328 patients (67%). The prevalence rates of newly diagnosed DM and impaired glucose regulation (IGR) were 22% and 45% respectively. Blood pressure, blood lipid, body mass index, waistline, and hemoglobin A1C were all significantly higher in those with glycometabolic perturbation than in those with normal glucose metabolism (all P < 0.05). Waistline and blood lipid were the risk factors of abnormal glycometabolic status (both P < 0.05). Newly diagnosed DM is common among the ACS patients without DM history. Newly diagnosed glycometabolic status is associated with waistline and blood lipid.