Abstract
A newer series of non-ionic Gemini amphiphiles have been synthesized using a novel A 2 B 2 type central core constituted by conjugating glycerol and propargyl bromide on 5-hydroxy isophthalic acid via multi-step chemo-enzymatic approach. A pair of hydrophilic monomethoxy polyethylene glycol (mPEG) and hydrophobic linear alkyl chains (C 12 /C 15 ) were then incorporated on the core to obtain amphiphilic architectures. The aggregation tendency in aqueous medium was studied by dynamic light scattering, fluorescence spectroscopy and cryogenic transmission electron microscopy. The nano-transport potential of the amphiphiles was studied for model hydrophobic guests, i.e. a dye Nile red and a drug Nimodipine by using UV-Vis and fluorescence spectroscopy. Evaluation of cell viability of amphiphile treated A549 cells showed them to be well tolerated up to the concentrations studied.
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