Newborn Screening for Severe Combined Immunodeficiency (SCID) in Ohio: Using Algorithms to Standardize Follow-up Limits the Number of False Positive Results

Rebecca Scherzer,Kimberly A Risma,Peter Mustillo,Ram Chandrasekar,Sharon Linard,Sherman Alter,Jack J.H Bleesing,Alexandra H Filipovich,Leigh A Kerns,Rebecca A Marsh,Velma Paschall,Nancy Wasserbauer,Rosemary Hage

doi:10.1016/j.jaci.2014.12.986

Newborn Screening for Severe Combined Immunodeficiency (SCID) in Ohio: Using Algorithms to Standardize Follow-up Limits the Number of False Positive Results

Rebecca Scherzer, Kimberly A Risma + Show 11 more

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https://doi.org/10.1016/j.jaci.2014.12.986

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Journal: Journal of Allergy and Clinical Immunology	Publication Date: Feb 1, 2015
Citations: 1

Affiliation: Nationwide Children's Hospital, Cincinnati Children's Hospital Medical Center, Ohio Department of Health, Dayton Children's Hospital, Rainbow Babies & Children's Hospital, Cleveland Clinic

#Number Of False Positive Results #T Cell Receptor Excision Circle + Show 8 more

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Abstract

T cell receptor excision circle (TREC) analysis on newborn screening (NBS) dried blood spot specimens has proven to be a successful method of screening for Severe Combined Immunodeficiency (SCID). We hypothesized that standardized algorithms for follow-up of abnormal values would decrease the number of false positives results.

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