Abstract
Typing of viruses and/or sera obtained from infants and/or mothers in 28 cases of neonatal infection with Herpesvirus hominis (HVH) provided evidence of type 2 HVH infection in 25 and type 1 HVH infection in 3 of the newborn infants. These laboratory findings, coupled with clinical information on some of the mothers, point strongly to the mother's infected genital tract (over 95 per cent are type 2 HVH) as the major source of herpetic infection in the newborn, thus providing possible approaches to prevention of this usually severe newborn infection. Several of the infected infants demonstrated elevations of IgM serum levels which appeared to correlate better with HVH antibodies detected by an indirect immunofluorescent technique than by neutralization tests.
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