Abstract
Organic and Medicinal chemistry international Journal is an open access journal that is committed to publish the papers on various topics of chemistry, especially synthetic organic chemistry, and pharmacology and various other biological specialties
Highlights
Cancer is one of the most widespread health diseases and causes high cancer-related mortality in both developing and developed countries
There are maximum drug molecules that interrupt microtubule/tubulin dynamics are most conventionally used in cancer treatment. tubulin, an α, β-heterodimer protein Binding that forms the core of microtubule
Taxanes interfere with tubulin dynamics and promote tubulin stabilization [3]
Summary
Submission: September 21, 2018; Published: September 27, 2018 *Corresponding author: Vinit Raj, Department of Pharmaceutical sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh, India, Email: Abstract. The main objective of present research hypothesis was to give the idea and taking the attention of researcher for tubulin as an anticancer drug target. Inhibiting tubulin by novel lead scaffold may be helpful to treat the cancer with reduced side effect and higher selectivity toward the cancer cells. The present problems with cancer drug have cancer cell resistant and adverse effects. Assisting the solution of this problem, we hypothesized; Pharmacophore based selection for new scaffold may exhibit better binding affinity and selectivity towards the tubulin assembly and suppressing microtubule formation and attenuating the adverse effects and resistant of drug molecules
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