Abstract
New Understanding of Fanconi Anemia Signaling Network upon Studying FANCD2
Highlights
The Fanconi Anemia (FA) pathway is activated upon replication stress and DNA damage
We aimed to update our understanding of FA signaling network with a focus on the center player, Fanconi Anemia complementation group D2 protein (FANCD2)
We described a recent recognized form of FANCD2, FANCD2-V2
Summary
Fanconi anemia is a rare genetic disease, characterized by developmental and physical abnormalities, bone marrow failure and increased cancer susceptibility [1,2,3,4,5,6,7,8,9]. FA gene products maintain genomic integrity and participate in a common DNA repair pathway- the FA/BRCA pathway [2,4,12,13]. Patients suffering from FA display high frequencies of chromosomal abnormalities and are hypersensitive to DNA crosslinking agents (i.e. mitomycin C, cisplatin, diepoxybutane) [1,3,5,6,8]. If DNA is not properly repaired it can lead to genomic instability, apoptosis, senescence and tumorigenesis [4,7]
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