Abstract
We have identified four new types of short conserved sequence domains in homing endonucleases and related proteins. These domains are modular, appearing in various combinations. One domain includes a motif known by structure as a novel sequence-specific DNA-binding helix. Sequence similarity shows two other domains to be new types of helix–turn–helix DNA-binding domains. We term the new domains nuclease-associated modular DNA-binding domains (NUMODs).
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