Abstract
Phytochemical investigation of the roots of Rhododendron molle led to the isolation of 15 new oleanane- and ursane-type triterpenoid compounds (1–15) along with 2 known triterpenoid compounds (16 and 17). The structures of the new compounds were determined by NMR analysis, ESIMS methods and X-ray diffraction. Notably, compound 1 is the first example of a 23-nor-ursane-type triterpenoid with 5/5/6/6/6/6-fused ring system. Compounds 2–5 are 7/6/6/6/6-fused triterpenoids. Compounds 6–9 are 23-nor-2,3-seco 6/6/6/6-fused triterpenoids. Compounds 10 and 11 are 3, 23, 24-trinor-2,4-seco 6/6/6/6-fused triterpenoids. In a membrane potential FLIPR assay, compounds 2, 14–17 (10 μM) induced the activation of GABAA receptors in the presence of GABA (0.2 μM), with increases in activation of 67.9%, 64.2%, 57.9% and 58%, respectively.
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