Abstract
• Two new compounds adinandrolide ( 1 ) and adipoiloside ( 2 ) were isolated. • Isolated compounds were evaluated for α -glucosidase inhibitory activity and cytotoxicity. • Compounds 5 - 7 and 10 showed strong α -glucosidase enzyme inhibition activity. • Pomolic acid ( 10 ) exhibited strong cytotoxicity against four tested cancer cell lines. Two new compounds, adinandrolide ( 1 ) and adipoiloside ( 2 ), together with twelve known compounds 3 – 14 , were isolated and identified from Adinandra poilanei leaves. In the α -glucosidase activity evaluation, compounds 5–7 and 10 strongly inhibited enzyme activity with IC 50 values ranging from 1.29 ± 0.03 μg/mL to 3.13 ± 0.07 μg/mL. Compounds 9 , 11 , and 13–14 showed significant inhibition with IC 50 values of 13.01 ± 0.32 μg/mL to 16.00 ± 0.35 μg/mL, while adipoiloside (2) displayed moderate inhibitory activity. In addition, pomolic acid ( 10 ) showed strong cytotoxicity against four tested cancer cell lines.
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