Abstract
Eight trichothecenes, including four new compounds 1–4 and four known entities 5–8, together with one known cyclonerane (9) were isolated from the solid-state fermentation of Trichoderma brevicompactum NTU439 isolated from the marine alga Mastophora rosea. The structures of 1–9 were determined by 1D/2D NMR (nuclear magnetic resonance), MS (mass spectrometry), and IR (infrared spectroscopy) spectroscopic data. All of the compounds were evaluated for cytotoxic activity against HCT-116, PC-3, and SK-Hep-1 cancer cells by the SRB assay, and compound 8 showed promising cytotoxic activity against all three cancer cell lines with the IC50 values of 3.3 ± 0.3, 5.3 ± 0.3, and 1.8 ± 0.8 μM, respectively. Compounds 1–2, 4–6, and 7–8 potently inhibited LPS-induced NO production, and compounds 5 and 8 showed markedly inhibited gelatinolysis of MMP-9 in S1 protein-stimulated THP-1 monocytes.
Highlights
Introduction published maps and institutional affilFungi are a potential source of drug leads that researchers are still seeking [1,2]
Of the solid culture of T. brevicompactum NTU439 isolated from a marine alga M. rosea, we isolated four new trichothecenes (1–4), together with five known com isolated four new trichothecenes (1–4), together with five known compounds, trichodermitrichoderminol
Trichothecenes comprise a group of sesquiterpenes that have been reported both from fungal cultures such as those of Myrothecium spp., Trichothecium spp., and Fusarium spp., as well as from some higher plants such as Bacchairis coridifolia, B. artemisioides, Ficus fistulosa, and Rhaphidophora decursiva [7,15,16,18,23,24]
Summary
Introduction published maps and institutional affilFungi are a potential source of drug leads that researchers are still seeking [1,2]. The discovery of new compounds with unique structural diversity and low molecular weight presents opportunities for discovering bioactive natural products from fungi [2]. A number of new compounds from marine fungi have been discovered from various sources, including extreme sea environment. These compounds showed various activities including anticancer, antimicroalgal, antibacterial, and antiviral effects [3,4,5]. Marine algae-derived fungi offer opportunities and attract attention because they produce secondary metabolites with unique chemical diversity and various pharmacological properties [4,6,8,9,10,11]
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