New Trends of Acetonitrile Moiety in Heterocyclic Synthesis: Synthesis of Some Novel Pyrazole Derivatives as Antibacterial and Antifungal Agents

Abstract

This manuscript describes the synthesis of novel series of pyrazole derivatives 4a–d, 6a–d, and 10a–d, and they were examined for their antimicrobial activity against Staphylococcus aureus and Streptococcus pyogenes as examples of Gram positive bacteria and Pseudomonas fluorescens and Pseudomonas phaseolicola as examples of Gram negative bacteria and also Fusarium oxysporum and Aspergillus fumigatus as fungal strains. Different methodologies were employed to construct this scaffold. Among these compounds, a series of pyrazole derivatives 4a–d and 6a–d exhibited a great degree of potency against some microbial strains including multidrug resistant strains. The structure of these compounds was confirmed on the basis of their analytical and spectral data such as UV–Vis, IR, 13C NMR, 1H NMR spectroscopy, and mass spectral data.