Abstract
Choroidal neovascularisation (CNV) can be a severe, sight-threatening sequela in patients with uveitis. CNV can occur in both infectious and non-infectious diseases. In the majority of cases, fluorescein angiography, indocyanine green angiography and optical coherence tomography allow the clinical characteristics of the CNV to be accurately determined. An infectious disease should be looked for so that patients can be given a suitable therapy when available. Regarding non-infectious inflammatory CNV, the treatment strategy should be aimed at controlling inflammation. Systemic corticosteroids with or without immunosuppressants are suggested, even when the CNV occurs with apparently inactive uveitis. In this case, chronic sub-clinical inflammation can be the basis for the CNV pathogenesis. Additional therapies aimed directly at the neovascular process, such as intravitreal antivascular endothelial growth factor agents, are recommended, particularly when the therapy shows insufficient efficacy. However, the current data are still only based on case reports or small series. For such reasons, further trials are mandatory to validate the preliminary results.
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