Abstract
BackgroundRecent studies have highlighted new botulinum neurotoxin (BoNT) applications in the field of dermatology.ObjectiveTo review current knowledge of BoNT use in dermatology.MethodsThe literature of the last 5 five years has been reviewed.ResultsWe describe interesting protocols of BoNT treatment for hyperhidrosis (HH), hypertrophic scars and keloids, Raynaud phenomenon, facial flushing, oily skin, psoriasis, Hailey-Hailey disease, and cutaneous lesions like painful lesions and periorbital syringomas.ConclusionsSeveral skin conditions eligible for BoNT treatment have been described. After the wide application for HH treatment, scars as well as vascular and inflammatory skin disorders, oily skin and cutaneous lesions represent fields of application of BoNT.
Highlights
The botulinum neurotoxin (BoNT) is produced by Clostridium botulinum bacteria
We describe interesting protocols of BoNT treatment for hyperhidrosis (HH), hypertrophic scars and keloids, Raynaud phenomenon, facial flushing, oily skin, psoriasis, Hailey-Hailey disease, and cutaneous lesions like painful lesions and periorbital syringomas
The difference between BoNT-A and B is the type of protein the light chain cleaves and different procedures in which they are employed [5]
Summary
Seven toxin isoforms can be distinguished (BoNT A-G) [1,2], with BoNT-A and B being commercially available for clinical applications. Both BoNTA and BoNT-B are proteins composed of a heavy and a light chain. These chains are related to the mechanism of action of the toxin. The heavy chain binds the BoNT to the cholinergic nerve terminal while the light chain inhibits the release of acetylcholine from presynaptic vesicles [3,4]. Recent studies have highlighted new botulinum neurotoxin (BoNT) applications in the field of dermatology
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