Abstract
Today's environmental balance has been compromised by the unreasonable and sometimes dangerous actions committed by humans to maintain their dominance over the Earth's natural resources. As a result, oceans are contaminated by the different types of plastic trash, crude oil coming from mismanagement of transporting ships spilling it in the water, and air pollution due to increasing production of greenhouse gases, such as CO2 and CH4 etc., into the atmosphere. The lands, agricultural fields, and groundwater are also contaminated by the infamous chemicals viz., polycyclic aromatic hydrocarbons, pyrethroids pesticides, bisphenol-A, and dioxanes. Therefore, bioremediation might function as a convenient alternative to restore a clean environment. However, at present, the majority of bioremediation reports are limited to the natural capabilities of microbial enzymes. Synthetic biology with uncompromised supervision of ethical standards could help to outsmart nature's engineering, such as the CETCH cycle for improved CO2 fixation. Additionally, a blend of synthetic biology with machine learning algorithms could expand the possibilities of bioengineering. This review summarized current state-of-the-art knowledge of the data-assisted enzyme redesigning to actively promote new research on important enzymes to ameliorate the environment.
Highlights
The present growth and development of modern human societies are sustained by the stability of the Holocene climate (Revell, 2020)
Bioremediation is an environment-friendly approach that uses the microbial enzyme to metabolize the pollutant as a nutrient for microbes (Vidali, 2001)
We have summarized current state-of-the-art knowledge of the dataassisted enzyme redesigning (Figure 1) to promote new studies on enzyme redesigning from an environmental perspective
Summary
The present growth and development of modern human societies are sustained by the stability of the Holocene climate (Revell, 2020). The invariability of the stable Holocene climate had been overwhelmingly abused by unrestrained consumption without genuine attention to the environment. Due to such negligence, the total wilderness of the earth has been dramatically reduced to only 35% of what it once was (Revell, 2020). Bioremediation is an environment-friendly approach that uses the microbial enzyme to metabolize the pollutant as a nutrient for microbes (Vidali, 2001). We have summarized current state-of-the-art knowledge of the dataassisted enzyme redesigning (Figure 1) to promote new studies on enzyme redesigning from an environmental perspective
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