Abstract
Multiple myeloma accounts for approximately 10% of hematologic malignancies, the frequency is constantly increasing due to aging of the general population.1,2 Recently, novel agents, such as thalidomide, bortezomib and lenalidomide have shown significant activity in multiple myeloma. Combinations of these agents with steroids, alkylating agents or anthracyclines have significantly improved response rate and progression- free survival (PFS). In elderly patients, older than 65 years, oral melphalan and prednisone (MP) has been combined with thalidomide or bortezomib significantly improving response rate and PFS.
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