New Theory of Respiratory Control and Regulation

Abstract

We recently finished ¡°Holistic Regulation of LifeCIntegrative Physiology¡± framework as a whole. The part of respiratory control and regulation is decribed as below: The key control of singles should be considered O2, while CO2 and [H+] act as subordinates to the core integration of breathing, circulation, metabolism, and other multi‐functional system control. The trigger to inhale during the termination of exhale is when the level of PO2 gradually decreases (PCO2 and [H+], opposite). The trigger to exhale during the termination of inhale is when the level of PO2 gradually increases (PCO2 and [H+], opposite), creating the cycle of breathing. Cardiovascular function is the key factor in determining a normal breathing rhythm and frequency. Regulation mode of breathing amplitude (depth): the next breath is induced as above to achieve a fast response through peripheral chemoreceptors. The breathing rate is exaggerated by the last breath, for example, a larger breath induces a larger breath, a smaller breath induces a smaller breath, and so on. Regulatory control the steady breathing pattern must be integration with slow response of central chemoreceptors.