Abstract
Results of efficiency assessment of different diagnosis for preinvasive cervical lesions are represented in the article. During investigation the retrospective analysis of 353 patient histories of women with cervical intraepithelial neoplasia (primary and recurrent), who have been observed in Ivanovskiy regional oncological dispensary from 2002 to 2011, was performed. The accuracy rates of diagnosis of cervical intraepithelial neoplasia for one or several methods including cytological study, colposcopy and fluorescence cystoscopy were compared. Fluorescence diagnosis was performed with drug fotoditazin (LLC «VETA-GRAND», marketing authorisation №LS 001246) at dose of 1,0 mg/kg body weight. The final diagnosis was determined by results of histological study. The accuracy of cytological study accounted for 67,5–80,7%. Using colposcopy the exact diagnosis was determined in 67,9–74,4% of cases. Combination of cytological study with colposcopy improved the accuracy of diagnosis up to 82.1–88.9%. The superior results were for concurrent use of cytological study with colposcopy and fluorescence diagnosis – in such case the diagnosis was correct in 92,0–96,7% of patients. The analysis of results showed that using all methods of diagnosis the accuracy of diagnosis for recurrent cervical intraepithelial neoplasia was lower than for primary lesions. The decrease of diagnosis accuracy is probably related to previous diagnosis and therapeutic manipulations on cervix. Thus, multimodal diagnosis investigation with methods of fluorescence spectroscopy allows to improve accuracy of diagnosis for preinvasive cervical lesions.
Highlights
Results of efficiency assessment of different diagnosis for preinvasive cervical lesions are represented in the article
who have been observed in Ivanovskiy regional oncological dispensary
Fluorescence diagnosis was performed with drug fotoditazin
Summary
Аминодова ОБУЗ «Ивановский областной онкологический диспансер», ООО «Клиника современной медицины», Иваново, Россия. В статье представлены результаты оценки эффективности различных методов диагностики преинвазивных заболеваний шейки матки. Сопоставлена точность диагностики дисплазии при использовании одной или нескольких методик исследования, в том числе цитологического исследования, кольпоскопии и флуоресцентной цистоскопии. Что точность диагностики цитологического исследования составляла 67,5–80,7%. Сочетанное применение цитологического исследования и кольпоскопии повысило точность диагностики до 82,1–88,9%. Наилучшие результаты показало одновременное применение цитологического исследования, кольпоскопии и флуоресцентной спектроскопии – в этом случае диагноз был поставлен верно у 92,0–96,7% пациенток. Что при использовании всех методик обследования точность диагностики рецидива дисплазии была несколько ниже, чем при впервые развившемся процессе. Комплексное проведение диагностических мероприятий с включением методик флуоресцентной спектроскопии позволяет повысить точность диагностики преинвазивных заболеваний шейки матки. Новые технологии в диагностике преинвазивных заболеваний шейки матки // Biomedical Photonics. Новые технологии в диагностике преинвазивных заболеваний шейки матки // Biomedical Photonics. – 2015. – Т. 4, No 4. – С. 11–16
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