Abstract
Leukemia T cell acute lymphoblastic leukemias (T-ALLs) are often caused by mutations in the gene encoding Notch1, which mediates cell-cell contact signaling. However, mice expressing these mutants frequently fail to develop T-ALL. Pajcini et al. found that the transcription factor MAFB increased the expression of Notch1 target genes in mouse and human T-ALL cells. Expressing MAFB enhanced the development of Notch1-mutant T-ALL in mice. Because Notch1 helps to maintain various adult tissues, developing a way to inhibit MAFB may provide a more targeted therapy for leukemia patients. Sci. Signal. 10 , eaam6846 (2017).
Published Version
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