Abstract
Abstract Synthesis of 1-trityl-2-phenylaziridine, 1-trityl-2-methylaziridine and 2-methylcarboxylates of 1-tritylaziridine, 1-trityl-3-methylaziridine, 1-trityl-3-phenylaziridine by reacting N-triphenylmethyl-α-chloroamines with KF in acetonitrile under reflux is described. Functionalized aziridines opened with hydrogen fluoride in pyridine (70 %) give isobutyl 3-fluoroalanine, methyl-3-fluorophenylalanine and methyl 2-amino-3-fluorobutyrate. N.M.R. 1 H and 19 F are discussed. The following reactions get the compounds in the table.
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