Abstract
AbstractThe solvent‐free fluorination of 2‐chloropyridine (III) with alkali metal fluorides and bifluorides was investigated. While complete degradation occurred with potassium fluoride at 315°, the use of potassium bifluoride under identical conditions provided a 74% yield of 2‐fluoro‐pyridine (II). Sodium bifluoride gave only a 3.5% yield of the desired product. These results are discussed in the light of: activation of the substrate, properties of the fluorinating agents, and the stability of 2‐fluoropyridine.
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