New synthesis of N1- and N2-substituted pyrazolo[4,3-b]pyridine-5-one derivatives as CB2 receptor ligands

Abstract

This synthesis of pyrazolo[4,3-b]pyridine-5-one derivatives, recently described as potent and selective agonists/inverse agonists of the cannabinoid type-2 receptor (CB2R), allows for a wider exploration of the structure-activity relationship.