New synthesis of heterocycles by use of palladium catalyzed cycli zation of α-haloamide with internal double bond

Abstract

α-Haloamide having internal double bond was allowed to react with a catalytic amount of Pd(PPh 3) 4 in the presence of base to produce a cyclized product in a fairly good yield possibly through the intermediate of -alkylmetal complex. By use of this method, five and six membered lactams, pyrrolizidine and quinolizidine derivatives were synthesized in fairly good yields.