Abstract

A method for the synthesis of desthiobiotin was developed. It is based on the reductive desulfurization of the lactam of δ -(5-bromo-4-nitro-3-amino-2-thienyl)valeric acid, saponification of the resulting ɛ-(1-aminoethyl-ɛ-enantholactam to 7,8-diaminopelargonic acid, and condensation of the latter with phosgene or urea.

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