Abstract
Both enantiomers of a 2-(4-pentenyl)pyrrolidine derivative 4 (65–90% ee), prepared via the asymmetric dihydroxylation (AD) of terminal olefin 2, underwent a second AD to provide all of the four stereoisomers of indolizidine 209D 1 with enantiomeric enhancement (92–98% ee). The affinity of 1 for nicotinic acetylcholine receptor was evaluated.
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