New strategy for the synthesis of N-aryl pyrroles: Cu-catalyzed C–N cross-coupling reaction of trans-4-hydroxy- l-proline with aryl halides

V Prakash Reddy,A Vijay Kumar,K Rama Rao

doi:10.1016/j.tetlet.2010.12.016

New strategy for the synthesis of N-aryl pyrroles: Cu-catalyzed C–N cross-coupling reaction of trans-4-hydroxy- l-proline with aryl halides

V Prakash Reddy, A Vijay Kumar + Show 1 more

https://doi.org/10.1016/j.tetlet.2010.12.016

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Journal: Tetrahedron Letters	Publication Date: Dec 9, 2010
Citations: 34

Affiliation: Indian Institute of Chemical Technology

#N-aryl Pyrroles #Aryl Halides + Show 8 more

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Abstract

trans-4-Hydroxy- l-proline is used for the first time as an effective nucleophilic coupling partner with aryl halides mediated by copper iodide with Cs 2CO 3 as the base and DMSO as the solvent. Utilizing this protocol cross-coupling of trans-4-hydroxy- l-proline with a wide variety of substituted aryl halides to produce N-aryl pyrroles in moderate to good yields.

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