Abstract
New 1-hydroxy-1-en-3-one derivatives of 18β- and 18α-glycyrrhetic acids were synthesized via oxidation of the 3-ketotriterpenoids by atmospheric oxygen in the presence of an excess of t-BuOK. 2-Hydroxy-3,11-dioxo-18αH-olean-1,12-dien-30-oic acid exhibited pronounced hypoglycemic activity and decreased the blood glucose concentration by 42.7% compared with a control after 120 min at a dose of 50 mg/kg in a rat alloxan-induced diabetes model.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
