Abstract
A new liquid chromatographic method has been developed for the simultaneous determination of Sofosbuvir and Velpatasvir in oral dosage forms. Shimadzu Model CBM-20A/20 Alite with C8 (Phenomenex) column (250 mm × 4.6 mm i.d., 5 µm particle size) was used for the chromatographic study. Linearity was observed over the concentration range 4.54-400.14 µg/ml and 1.09-100.36 µg/ml with regression equations y = 26855x + 83874 (correlation coefficient 0.9997) and y = 35840x + 8543.8 (correlation coefficient 0.9999) for Sofosbuvir and Velpatasvir respectively. Sofosbuvir and Velpatasvir were subjected to forced degradation and the method was validated as per ICH guidelines.
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