Abstract
Pterostilbene is used for the treatment of cancer, diabetes, anti-hyperlipidemic and fungal infections.A new RP-UFLC method has been developed for the determination of Pterostilbene. Shimadzu Model UFLC system, equipped with PDA detector and SunfireC18 column was used for the present chromatographic study. Mobile phase consisting of a mixture of tetra butyl ammonium hydrogen sulphate andacetonitrile (32:68, v/v)with flow rate 1.0 mL/min was chosen for the determination of Pterostilbene. Linearity was observed over the concentration range 0.1–100 µg/ml (R2 = 0.9999) with linear regression equation y = 161775.7385x - 15849.1207. The LOD and LOQ were found to be 0.01642 µg/ml and 0.05421 µg/ml respectively. Solutions of Pterostilbenewere subjected to stress conditions such as acidic, alkaline, oxidation and thermal degradations. The method was validatedas per ICH guidelines. This method is quite suitable for the determination of Pterostilbene in pharmaceutical formulations.
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